As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-
carbon metabolism involving folate and homocysteine metabolisms. It is known that some …

Alzheimer's disease (AD) is the most common cause of dementia. Despite this, clear
pathophysiology for AD has not been confirmed, and effective treatments are still not …

The primordial small gaseous molecules, such as: NO, CO, H 2 S and formaldehyde (FA)
are present in the brains. Whether FA as well as the other molecules participates in brain …

Background: Recent studies have reported that homocysteine (Hcy) may play a vital role in
the pathogenesis of vascular dementia (VaD) and Alzheimer's disease (AD). Our study …

Recent progresses in high-throughput technologies have led to a new scenario in
investigating pathologies, named the “Omics era”, which integrate the opportunity to collect …

Background: Neuroinflammation plays an important role in Alzheimer's disease (AD). During
this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL) …

Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate/homocysteine
metabolic pathway. C677T polymorphism of MTHFR gene was reported as risk factor for …

Methylenetetrahydrofolate reductase (MTHFR) is key enzyme of folate/homocysteine
pathway. Case control association studies on MTHFR C677T polymorphism and Alzheimer's …

Alzheimer's disease (AD) is a neurodegenerative disorder, marked by cortical and
hippocampal deposition of amyloid-β (Aβ) plaques and neurofibrillary tangles and cognitive …