The protein kinase mechanistic target of rapamycin (mTOR) functions as a central regulator
of metabolism, integrating diverse nutritional and hormonal cues to control anabolic …

Dietary polyphenols can be utilized to treat obesity and chronic disorders linked to it. Dietary
polyphenols can inhibit pre-adipocyte proliferation, adipocyte differentiation, and triglyceride …

Cold acclimation and pharmacological peroxisome proliferator-activated receptor γ (PPARγ)
activation have each earlier been shown to recruit brown adipose tissue (BAT) and beige …

Neurolysin oligopeptidase (EC 3.4. 24.16; Nln), a member of the zinc metallopeptidase M3
family, was first identified in rat brain synaptic membranes hydrolyzing neurotensin at the …

Exposure to low ambient temperatures has previously been demonstrated to markedly
improve glucose homeostasis in both rodents and humans. Although the brown adipose …

Total absence of adipose tissue (lipoatrophy) is associated with the development of severe
metabolic disorders including hepatomegaly and fatty liver. Here, we sought to investigate …

Metabolic diseases such as obesity and diabetes are often thought to be caused by reduced
energy expenditure, which poses a serious threat to human health. Cold exposure, exercise …

In eukaryotic cells, the mammalian target of rapamycin complex 1 (sometimes referred to as
the mechanistic target of rapamycin complex 1; mTORC1) orchestrates cellular metabolism …

Chronic and excessive glucocorticoid (GC) exposure can cause Cushing's syndrome,
resulting in fat accumulation in selected body areas. Particularly in the brown adipose tissue …

Brown adipose tissue (BAT) thermogenesis results from the uncoupling of mitochondrial
inner membrane proton gradient mediated by the uncoupling protein 1 (UCP-1), which is …