Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …

Targeting TEAD autopalmitoylation has been proposed as a therapeutic approach for YAP-
dependent cancers. Here we show that TEAD palmitoylation inhibitor MGH-CP1 and …

Research of the past view years expanded our understanding of the various physiological
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …

SOX4 is an essential developmental transcription factor that regulates stemness,
differentiation, progenitor development, and multiple developmental pathways including …

Sex-determining region Y-related (SRY) high-mobility group box 4 (SOX4) is a member of
the group C subfamily of SOX transcription factors and promotes tumorigenesis by endowing …

Mounting evidence highlights long non‐coding RNAs (lncRNAs) as crucial regulators in
multiple types of biological processes and contributing to tumourigenesis. LINC01133 …

Breast cancer is one of the most common cancers among women. Long non-coding RNAs
(lncRNAs) are involved in the initiation and development of breast cancer and lncRNA H19 …

Abstract Background Cancer stem cells (CSCs) are the root of human cancer development
and the major cause of treatment failure. Aberrant elevation of SOX4, a member of SOX …