Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Physical activity is one of the modifiable factors of cognitive decline and dementia with the
strongest evidence. Although many influential reviews have illustrated the neurobiological …

Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …

Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional
deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity …

The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …

Multiple sclerosis (MS) is the most frequent chronic inflammatory disease of the CNS, and
imposes major burdens on young lives. Great progress has been made in understanding …

Engagement in regular bouts of exercise confers numerous positive effects on brain health
across the lifespan. Acute bouts of exercise transiently improve cognitive function, while long …

Exercise is known to induce a cascade of molecular and cellular processes that support
brain plasticity. Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin that is …