Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

Generation of surrogate cells with stable functional identities is crucial for developing cell-
based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes …

Type 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by
elevated blood glucose. Multiple environmental and genetic factors can increase the risk of …

Caloric restriction (CR) can extend the organism life-and health-span by improving glucose
homeostasis. How CR affects the structure-function of pancreatic beta cells remains …

G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit, primarily expressed
in pancreatic islet β cells, which modulates the sensitivity of insulin secretion to glucose and …

Neuropeptides (NPs) and their cognate receptors are critical effectors of diverse
physiological processes and behaviors. We recently reported of a noncanonical function of …

Conventional measurements of fasting and postprandial blood glucose levels investigated
in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on …

G6PC2 encodes a glucose-6-phosphatase (G6Pase) catalytic subunit that modulates the
sensitivity of insulin secretion to glucose and thereby regulates fasting blood glucose (FBG) …

Elevated fasting blood glucose (FBG) is associated with increased risks of developing type 2
diabetes (T2D) and cardiovascular-associated mortality. G6PC2 is predominantly expressed …

In the endoplasmic reticulum (ER) lumen, glucose-6-phosphatase catalytic subunit 1 and 2
(G6PC1; G6PC2) hydrolyze glucose-6-phosphate (G6P) to glucose and inorganic …