Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

In 46, XY men, testis is determined by a genetic network (s) that both promotes testis
formation and represses ovarian development. Disruption of this process results in a lack of …

Glial cells in the central nervous system (CNS) are composed of oligodendrocytes,
astrocytes and microglia. They contribute more than half of the total cells of the CNS, and are …

Growing evidence indicates that non-neuronal mutant huntingtin toxicity plays an important
role in Huntington's disease (HD); however, whether and how mutant huntingtin affects …

The transcription factors Olig2 and Sox10 jointly define oligodendroglial identity. Because of
their continuous presence during development and in the differentiated state they shape the …

Congenital diaphragmatic hernia (CDH) is a severe birth defect that is often accompanied by
other congenital anomalies. Previous exome sequencing studies for CDH have supported a …

The nematode Caenorhabditis elegans is a research model organism particularly suited to
the mechanistic understanding of synapse genesis in the nervous system. Armed with …

Oligodendrocytes generate myelin in the vertebrate central nervous system and thus ensure
rapid propagation of neuronal activity. Their development is controlled by a network of …

Membrane-bound transcription factors (MTFs) are transcription factors (TFs) that are
anchored in membranes in a dormant state. Activated by external or internal stimuli, MTFs …

Nanophthalmos is a rare, potentially devastating eye condition characterized by small eyes
with relatively normal anatomy, a high hyperopic refractive error, and frequent association …