Exploring the Role of Enhancer-Mediated Transcriptional Regulation in Precision Biology

X Wang, D Liu, J Luo, D Kong, Y Zhang - International Journal of …, 2023 - mdpi.com
The emergence of precision biology has been driven by the development of advanced
technologies and techniques in high-resolution biological research systems. Enhancer …

RevGel-seq: instrument-free single-cell RNA sequencing using a reversible hydrogel for cell-specific barcoding

J Komatsu, A Cico, R Poncin, M Le Bohec, J Morf… - Scientific Reports, 2023 - nature.com
Progress in sample preparation for scRNA-seq is reported based on RevGel-seq, a
reversible-hydrogel technology optimized for samples of fresh cells. Complexes of one cell …

A composite scaling network of EfficientNet for improving spatial domain identification performance

Y Zhao, C Long, W Shang, Z Si, Z Liu, Z Feng… - Communications …, 2024 - nature.com
Spatial Transcriptomics leverages gene expression profiling while preserving spatial
location and histological images. However, processing the vast and noisy image data in …

[HTML][HTML] AtML: An Arabidopsis thaliana root cell identity recognition tool for medicinal ingredient accumulation

S Yu, L Liu, H Wang, S Yan, S Zheng, J Ning, R Luo… - Methods, 2024 - Elsevier
Arabidopsis thaliana synthesizes various medicinal compounds, and serves as a model
plant for medicinal plant research. Single-cell transcriptomics technologies are essential for …

GametesOmics: A Comprehensive Multi-omics Database for Exploring the Gametogenesis in Humans and Mice

J An, J Wang, S Kong, S Song, W Chen… - Genomics …, 2024 - academic.oup.com
Gametogenesis plays an important role in the reproduction and evolution of species. The
transcriptomic and epigenetic alterations in this process can influence the reproductive …

Deciphering the decisive factors driving fate bifurcations in somatic cell reprogramming

C Long, H Li, P Liang, L Chao, Y Hong, J Zhang… - … Therapy-Nucleic Acids, 2023 - cell.com
Single-cell studies have demonstrated that somatic cell reprogramming is a continuous
process of cell fates transition. Only partial reprogramming intermediates can overcome the …

Disease trend analysis platform accurately predicts the occurrence of cervical cancer under mixed diseases

Y Liang, Y Guo, Y Zhai, J Zhou, W Yang, Y Zuo - Methods, 2024 - Elsevier
Cervical cancer (CC) is one of the most common gynecological malignancies. Cytological
screening, while being the most common and accurate method for detecting cervical cancer …

Predicting genome‐wide tissue‐specific enhancers via combinatorial transcription factor genomic occupancy analysis

H Shireen, F Batool, H Khatoon, N Parveen… - FEBS …, 2024 - Wiley Online Library
Enhancers are non‐coding cis‐regulatory elements crucial for transcriptional regulation.
Mutations in enhancers can disrupt gene regulation, leading to disease phenotypes …

Epigenetics of genes preferentially expressed in dissimilar cell populations: Myoblasts and cerebellum

M Ehrlich, KC Ehrlich, M Lacey, C Baribault, S Sen… - Epigenomes, 2024 - mdpi.com
While studying myoblast methylomes and transcriptomes, we found that CDH15 had a
remarkable preference for expression in both myoblasts and cerebellum. To understand …

[HTML][HTML] An increment of diversity method for cell state trajectory inference of time-series scRNA-seq data

Y Hong, H Li, C Long, P Liang, J Zhou, Y Zuo - Fundamental Research, 2024 - Elsevier
The increasing emergence of the time-series single-cell RNA sequencing (scRNA-seq) data,
inferring developmental trajectory by connecting transcriptome similar cell states (ie, cell …