Enhancers control the establishment of spatiotemporal gene expression patterns throughout
development. Over the past decade, the development of new technologies has improved our …

The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or
synergistically, to maintain and enforce a repressive state of the target chromatin, thereby …

Resistance to cancer treatment remains a major clinical hurdle. Here, we demonstrate that
the CoREST complex is a key determinant of endocrine resistance and ER+ breast cancer …

Summary Polycomb repressive complex 1 (PRC1) is a key transcriptional regulator in
development via modulating chromatin structure and catalyzing histone H2A ubiquitination …

Advanced genomic and molecular profiling technologies accelerated the enlightenment of
the regulatory mechanisms behind cancer development and progression, and the targeted …

Enzymes of the ten-eleven translocation (TET) family play a key role in the regulation of
gene expression by oxidizing 5-methylcytosine (5mC), a prominent epigenetic mark in many …

Chromatin architecture regulates gene expression and shapes cellular identity, particularly
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …

Transcription factors (TFs) regulate gene expression by binding with varying strengths to
DNA via their DNA-binding domain. Additionally, some TFs also interact with RNA, which …

Abstract Arabidopsis NODULIN HOMEOBOX (NDX) is a nuclear protein described as a
regulator of specific euchromatic genes within transcriptionally active chromosome arms …

Polycomp group (PcG) proteins are members of highly conserved multiprotein complexes,
recognized as gene transcriptional repressors during development and shown to play a role …