Wolfram syndrome is a rare multisystem disorder caused by mutations in WFS1 or CISD2
genes leading to brain structural abnormalities and neurological symptoms. These …

Wolfram syndrome is a rare neurodegenerative disorder that is typically characterized by
diabetes mellitus and optic atrophy. Other common features are diabetes insipidus and …

Objective Wolfram syndrome (WS) is a rare neurodegenerative disorder characterized by
juvenile‐onset diabetes mellitus and optic atrophy. Our aim was to describe the nature and …

Wolfram Syndrome (WFS) is a rare autosomal recessive disease characterized by insulin-
dependent diabetes mellitus, optic nerve atrophy, diabetes insipidus, deafness, and …

The prevalence of the syndrome on the basis of the nationwide study in UK (published by
Barrett etal.) was estimated to be around 1 in 770 000 individuals. The prevalence in …

Advancements in ocular imaging have significantly broadened our comprehension of
mitochondrial retinopathies and optic neuropathies by examining the structural and …

Background: Wolfram syndrome (WS) is a rare autosomal recessive disorder that is
characterized by the presence of diabetes mellitus, optic atrophy and hearing loss, all of …

OBJECTIVE—Wolfram syndrome is an autosomal recessive neurodegenerative disorder
characterized by diabetes insipidus, diabetes (nonautoimmune), optic atrophy, and …

PURPOSE To describe the clinical phenotype of a cohort of patients with Wolfram syndrome
(WS), focusing on the pattern of optic atrophy correlated with brain magnetic resonance …

Wolfram syndrome (WS), also known as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus,
Optic Atrophy and Deafness), is a neurodegenerative disease with autosomal recessive …