Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Fungal secondary metabolites are small molecules that exhibit diverse biological activities
exploited in medicine, industry and agriculture. Their biosynthesis is governed by co …

Abstract Background Peptidyl-prolyl isomerases (PPIases) are enzymes that assist in the
folding of newly-synthesized proteins and regulate the stability, localization, and activity of …

There is accumulating evidence indicating a close crosstalk between key molecular events
regulating cell growth and proliferation, which could profoundly impact carcinogenesis and …

NMR is an essential technique for obtaining information at atomic resolution on the structure,
motions and interactions of biomolecules. Here, we review the contribution of NMR to our …

Gene transcription responds to stress and metabolic signals to optimize growth and survival.
Histone H3 (H3) lysine 4 trimethylation (K4me3) facilitates state changes, but how levels are …

FK506 binding proteins (FKBPs) catalyze the interconversion of cis-trans proline conformers
in proteins. Importantly, FK506 drugs have anti-cancer and neuroprotective properties, but …

Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and
an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with …

Arabidopsis thaliana CYP71 (AtCYP71) is a chromatin‐remodeling protein that promotes
shoot apical meristem (SAM) differentiation. The N terminus of AtCYP71 contains a …

Centromeric identity and chromosome segregation are determined by the precise
centromeric targeting of CENP-A, the centromere-specific histone H3 variant. The …