Genome-scale models in human metabologenomics
A Mardinoglu, BØ Palsson - Nature Reviews Genetics, 2025 - nature.com
Metabologenomics integrates metabolomics with other omics data types to comprehensively
study the genetic and environmental factors that influence metabolism. These multi-omics …
study the genetic and environmental factors that influence metabolism. These multi-omics …
A biological guide to glycosaminoglycans: current perspectives and pending questions
S Ricard‐Blum, RR Vivès, L Schaefer… - The FEBS …, 2024 - Wiley Online Library
Mammalian glycosaminoglycans (GAGs), except hyaluronan (HA), are sulfated
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …
polysaccharides that are covalently attached to core proteins to form proteoglycans (PGs) …
Noninvasive detection of any-stage cancer using free glycosaminoglycans
Cancer mortality is exacerbated by late-stage diagnosis. Liquid biopsies based on genomic
biomarkers can noninvasively diagnose cancers. However, validation studies have …
biomarkers can noninvasively diagnose cancers. However, validation studies have …
High-throughput glycosaminoglycan extraction and UHPLC-MS/MS quantification in human biofluids
N Volpi, F Galeotti, F Gatto - Nature Protocols, 2024 - nature.com
Glycosaminoglycans (GAGs) are linear, unbranched heteropolysaccharides whose
structural complexity determines their function. Accurate quantification of GAGs in biofluids …
structural complexity determines their function. Accurate quantification of GAGs in biofluids …
Analysis of normal levels of free glycosaminoglycans in urine and plasma in adults
S Bratulic, A Limeta, F Maccari, F Galeotti… - Journal of Biological …, 2022 - ASBMB
Plasma and urine glycosaminoglycans (GAGs) are long, linear sulfated polysaccharides that
have been proposed as potential noninvasive biomarkers for several diseases. However …
have been proposed as potential noninvasive biomarkers for several diseases. However …
Plasma and urine free glycosaminoglycans as monitoring and predictive biomarkers in metastatic renal cell carcinoma: a prospective cohort study
PURPOSE No liquid biomarkers are approved in metastatic renal cell carcinoma (mRCC)
despite the need to predict and monitor response noninvasively to tailor treatment choices …
despite the need to predict and monitor response noninvasively to tailor treatment choices …
[HTML][HTML] Discriminating Benign from Malignant Lung Diseases Using Plasma Glycosaminoglycans and Cell-Free DNA
A Qvick, S Bratulic, J Carlsson, B Stenmark… - International Journal of …, 2024 - mdpi.com
We aimed to investigate the use of free glycosaminoglycan profiles (GAGomes) and cfDNA
in plasma to differentiate between lung cancer and benign lung disease, in a cohort of 113 …
in plasma to differentiate between lung cancer and benign lung disease, in a cohort of 113 …
[HTML][HTML] Plasma and urine free glycosaminoglycans as monitoring biomarkers in nonmetastatic renal cell carcinoma—a prospective cohort study
Background No liquid biomarkers are approved in renal cell carcinoma (RCC), making early
detection of recurrence in surgically treated nonmetastatic (M0) patients dependent on …
detection of recurrence in surgically treated nonmetastatic (M0) patients dependent on …
Plasma glycosaminoglycans and cell-free DNA to discriminate benign and malignant lung diseases
A Qvick, S Bratulic, J Carlsson, B Stenmark, C Karlsson… - medRxiv, 2024 - medrxiv.org
We aimed to investigate the use of free glycosaminoglycan profiles (GAGomes) and cfDNA
in plasma to differentiate between lung cancer and benign lung disease. GAGs were …
in plasma to differentiate between lung cancer and benign lung disease. GAGs were …
Interlaboratory evaluation of LC–MS-based biomarker assays
K Saito, R Goda, K Arai, K Asahina, M Kawabata… - Bioanalysis, 2024 - Taylor & Francis
Validation of biomarker assays is crucial for effective drug development and clinical
applications. Interlaboratory reproducibility is vital for reliable comparison and combination …
applications. Interlaboratory reproducibility is vital for reliable comparison and combination …