Lessons from acquired natural immunity and clinical trials to inform next-generation human cytomegalovirus vaccine development

X Hu, HY Wang, CE Otero, JA Jenks… - Annual review of …, 2022 - annualreviews.org
Human cytomegalovirus (HCMV) infection, the most common cause of congenital disease
globally, affecting an estimated 1 million newborns annually, can result in lifelong sequelae …

Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation

MR Sponholtz, PO Byrne, AG Lee… - Proceedings of the …, 2024 - pnas.org
Human cytomegalovirus (HCMV) glycoprotein B (gB) is a class III membrane fusion protein
required for viral entry. HCMV vaccine candidates containing gB have demonstrated …

[HTML][HTML] Proceedings of the Conference “CMV Vaccine Development—How Close Are We?”(27–28 September 2023)

MR Schleiss, CM Crooks, KP Karthigeyan, RM Kruc… - 2024 - mdpi.com
Congenital cytomegalovirus (cCMV) is the most common infectious cause of disability in
children, including sensorineural hearing loss. There is interest in developing a pre …

A broadly neutralizing human monoclonal antibody generated from transgenic mice immunized with HCMV particles limits virus infection and proliferation

KE Atanasoff, AJ Parsons, SI Ophir, N Lurain… - Journal of …, 2024 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a β-herpesvirus that poses severe disease risk for
immunocompromised patients who experience primary infection or reactivation …

[HTML][HTML] An enveloped virus-like particle alum-adjuvanted cytomegalovirus vaccine is safe and immunogenic: A first-in-humans Canadian Immunization Research …

JM Langley, S Gantt, SA Halperin, B Ward, S McNeil… - Vaccine, 2024 - Elsevier
Introduction Cytomegalovirus (CMV) is the most common cause of congenital infection and
affected children often have permanent neurodevelopmental sequelae, including hearing …

Computational design of prefusion-stabilized Herpesvirus gB trimers

M McCallum, D Veesler - bioRxiv, 2024 - biorxiv.org
In the absence of effective vaccines, human-infecting members of the Herpesvirus family
cause considerable morbidity and mortality worldwide. Herpesvirus infection relies on …

A human cytomegalovirus prefusion-like glycoprotein B subunit vaccine elicits similar humoral immunity to that of postfusion gB in mice

KP Karthigeyan, M Connors, CR Binuya, M Gross… - bioRxiv, 2024 - biorxiv.org
Human cytomegalovirus (HCMV) is the leading infectious cause of birth defects. Despite the
global disease burden, there is no FDA-approved HCMV vaccine. The most efficacious …

Characterization and Evaluation of Anti-HCMV Biologics Targeting Entry as Novel Therapeutics and Potential Components of a Multifaceted Treatment Strategy

KE Atanasoff - 2024 - search.proquest.com
Human cytomegalovirus (HCMV) is a β-herpesvirus that poses severe risk for
immunocompromised patients. Development and optimization of effective anti-HCMV …