Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts

D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …

Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal

H Nishizawa, M Yamanaka, K Igarashi - The FEBS journal, 2023 - Wiley Online Library
Ferroptosis is triggered by a chain of intracellular labile iron‐dependent peroxidation of cell
membrane phospholipids. Ferroptosis is important not only as a cause of ischaemic and …

[HTML][HTML] Parkinson's disease: alterations in iron and redox biology as a key to unlock therapeutic strategies

L Ma, MG Azad, M Dharmasivam, V Richardson… - Redox biology, 2021 - Elsevier
A plethora of studies indicate that iron metabolism is dysregulated in Parkinson's disease
(PD). The literature reveals well-documented alterations consistent with established dogma …

Ferroptosis and senescence: A systematic review

D Coradduzza, A Congiargiu, Z Chen, A Zinellu… - International Journal of …, 2023 - mdpi.com
Senescence is a cellular aging process in all multicellular organisms. It is characterized by a
decay in cellular functions and proliferation, resulting in increased cellular damage and …

Ferroptosis-a new target of osteoporosis

Z Gao, Z Chen, Z Xiong, X Liu - Experimental gerontology, 2022 - Elsevier
Osteoporosis is a bone metabolic disease characterized by reduced bone mass and
deterioration of bone tissue microarchitecture, leading to enhanced skeletal fragility and …

Embryonal erythropoiesis and aging exploit ferroptosis

H Zheng, L Jiang, T Tsuduki, M Conrad, S Toyokuni - Redox biology, 2021 - Elsevier
Ferroptosis is a form of regulated cell necrosis, as a consequence of Fe (II)-dependent lipid
peroxidation. Although ferroptosis has been linked to cancer cell death, neurodegeneration …

Ferroptosis: The entanglement between traditional drugs and nanodrugs in tumor therapy

K Liu, L Huang, S Qi, S Liu, W Xie, L Du… - Advanced …, 2023 - Wiley Online Library
Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid
peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main …

Implication of ferroptosis in aging

M Mazhar, AU Din, H Ali, G Yang, W Ren, L Wang… - Cell Death …, 2021 - nature.com
Life is indeed continuously going through the irreversible and inevitable process of aging.
The rate of aging process depends on various factors and varies individually. These factors …

The transcription factor BACH1 at the crossroads of cancer biology: from epithelial–mesenchymal transition to ferroptosis

K Igarashi, H Nishizawa, Y Saiki… - Journal of Biological …, 2021 - ASBMB
The progression of cancer involves not only the gradual evolution of cells by mutations in
DNA but also alterations in the gene expression induced by those mutations and input from …

[HTML][HTML] Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate

L Jiang, H Zheng, Q Lyu, S Hayashi, K Sato, Y Sekido… - Redox Biology, 2021 - Elsevier
Abstract Non-thermal plasma (NTP), an engineered technology to generate reactive
species, induces ferroptosis and/or apoptosis specifically in various-type cancer cells. NTP …