The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Covering: up to 2015 This review summarises the accumulated knowledge about
characterised bacterial terpene cyclases. The structures of identified products and of …

Bacterial natural products (NPs) and their analogs constitute more than half of the new small
molecule drugs developed over the past few decades. Despite this success, interest in …

Engineering sesquiterpene synthases to form predefined alternative products is a major
challenge due to their diversity in cyclization mechanisms and our limited understanding of …

An uncharacterized terpene cyclase from Streptomyces pratensis was identified as (+)‐(1
(10) E, 4E, 6S, 7R)‐germacradien‐6‐ol synthase. The enzyme product exists as two …

The post-genomic era has provided researchers with a deluge of protein sequences.
However, a significant fraction of the proteins encoded by sequenced genomes remains …

Terpenes are the largest class of natural products with extensive structural diversity and are
widely used as pharmaceuticals, herbicides, flavourings, fragrances, and biofuels. While …

Terpenoids derived from plant material are widely applied in the flavor and fragrance
industry. Traditional extraction methods are unsustainable, but microbial synthesis offers a …

Prenyltransferase (PT) and terpene synthase (TPS) are key enzymes in the formation of the
basic carbon skeletons of terpenoids. The PTs determine the prenyl carbon chain length …