Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

ATP acts as a humoral mediator to control cell function extracellularly. The receptors that
mediate the actions of ATP belong to two classes, the metabotropic P2Y receptors and the …

ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation
when released from damaged tissue1-10. Here we report the molecular cloning and …

Cation-selective P2X receptor channels were first described in sensory neurons1-4 where
they are important for primary afferent neurotransmission and nociception5, 6. Here we …

A cDNA encoding a novel member of the G-protein-coupled receptor (GCR) superfamily, an
ATP receptor, has been isolated from an embryonic chick whole brain cDNA library by …

ATP is found in every cell, where it is a major source of energy. But in the nervous system,
ATP also has additional actions, which include its role in fast synaptic transmission and …

The evidence for release of vasoactive substances from endothelial cells in response to
shear stress caused by the viscous drag of passing fluids is reviewed and, in particular, its …

P2X receptors are a family of ligand-gated ion channels, activated by extracellular ATP. The
seven subunits cloned (P2X1–7) can assemble to form homomeric and heteromeric …

Of the cloned P2X receptor subunits, six are expressed in sensory neurons, suggesting that
the native channels may be heteromultimers with diverse composition. It has been proposed …

The potential importance for nociception of P2X receptors, the ionotropic receptors activated
by ATP, is underscored by the variety of pain states in which this endogenous ligand can be …