Flavin-containing monooxygenases (FMOs) are drug-oxygenating enzymes that are present
in the human genome as FMO1-5 and FMO6P. Among pig, dog, and cat FMOs, pig and dog …

The defense against influenza virus (IV) infections still poses a series of challenges. The
current antiviral arsenal against influenza viruses is in fact limited; therefore, the …

Indigoids are well-known dye molecules of widespread industrial applications in textiles as
well as more recently in pharmaceuticals. Historically they have been predominantly …

Biocatalysis using flavoprotein monooxygenases is coming of age, with intense research
and development being carried out within the last decade. The reason behind their …

Drug oxygenation is mainly mediated by cytochromes P450 (P450s, CYPs) and flavin-
containing monooxygenases (FMOs). Polymorphic variants of P450s and FMOs are known …

Human flavin-containing monooxygenase 3 (FMO3, EC 1.14. 13.8) in liver catalyzes a
variety of oxygenations of nitrogen-and sulfur-containing medicines and xenobiotic …

Flavin-containing monooxygenases (FMOs) are a family of important drug oxygenation
enzymes that, in humans, consist of five functional enzymes (FMO1–5) and a pseudogene …

It is highly advantageous to devise an in vitro platform that can predict the complexity of an in
vivo system. The first step of this process is the identification of a xenobiotic whose …

Liver microsomal flavin-containing monooxygenases (FMO, EC 1.14. 13.8) 1 and 3 were
functionally characterized in terms of expression levels and molecular catalytic capacities in …

Benzydamine is an anti-inflammatory drug that undergoes flavin-containing
monooxygenase (FMO)-dependent metabolism to benzydamine N-oxide; however …