B. DNA binding properties C. PPAR ligand-binding properties D. Alternative pathways for
PPAR activation E. PPAR-mediated transactivation properties III. Physiological Aspects A …

The past twenty years have seen great strides in our understanding of the molecular
regulation of differentiation for a whole host of specific cell types. The development of …

Muscle satellite cells are believed to represent a committed stem cell population that is
responsible for the postnatal growth and regeneration of skeletal muscle. However, the …

An outstanding question in adipocyte biology is how hormonal cues are relayed to the
nucleus to activate the transcriptional program that promotes adipogenesis. The forkhead …

Myostatin, a transforming growth factor β (TGF-β) family member, is a potent negative
regulator of skeletal muscle growth. In this study we characterized the myostatin signal …

Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein
α (C/EBPα) are key activators of adipogenesis. They mutually induce the expression of each …

The peroxisome proliferator-activated receptor gamma (PPAR γ) quickly evolved over the
last decade from a new orphan receptor to one of the best characterized nuclear receptors …

Suppressing hyperactive endocannabinoid tone is a critical target for reducing obesity. The
backbone of both endocannabinoids 2‐arachidonoylglycerol (2‐AG) and anandamide …

We have explored the effects of two members of the p160 coregulator family on energy
homeostasis. TIF2−/− mice are protected against obesity and display enhanced adaptive …

Background & Aims: Proliferation and migration of hepatic stellate cells (HSCs) and
expression of chemokines are involved in the pathogenesis of liver inflammation and …