Circadian rhythms and the molecular clock in cardiovascular biology and disease

S Crnko, BC Du Pré, JPG Sluijter… - Nature Reviews …, 2019 - nature.com
The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism—
circadian rhythmicity—to anticipate the daily changes caused by this rotation. The molecular …

Circadian clock-mediated regulation of blood pressure

LG Douma, ML Gumz - Free radical biology and medicine, 2018 - Elsevier
Most bodily functions vary over the course of a 24 h day. Circadian rhythms in body
temperature, sleep-wake cycles, metabolism, and blood pressure (BP) are just a few …

Sleep irregularity and risk of cardiovascular events: the multi-ethnic study of atherosclerosis

T Huang, S Mariani, S Redline - Journal of the American College of …, 2020 - jacc.org
Background The cardiovascular system exhibits strong circadian rhythms to maintain normal
functioning. Irregular sleep schedules, characterized by high day-to-day variability in sleep …

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

I AlZaim, LPMH de Rooij, BN Sheikh… - Nature Reviews …, 2023 - nature.com
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic
metabolic homeostasis. Additionally, adipose tissue is a pivotal regulator of cardiovascular …

Circadian rhythm and disease: Relationship, new insights, and future perspectives

AR Neves, T Albuquerque, T Quintela… - Journal of cellular …, 2022 - Wiley Online Library
The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

Health consequences of circadian disruption in humans and animal models

JA Evans, AJ Davidson - Progress in molecular biology and translational …, 2013 - Elsevier
Daily rhythms in behavior and physiology are programmed by a hierarchical collection of
biological clocks located throughout the brain and body, known as the circadian system …

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

T Eckle, K Hartmann, S Bonney, S Reithel… - Nature medicine, 2012 - nature.com
Adenosine signaling has been implicated in cardiac adaptation to limited oxygen
availability. In a wide search for adenosine receptor A2b (Adora2b)-elicited cardioadaptive …

Outdoor light at night and risk of coronary heart disease among older adults: a prospective cohort study

S Sun, W Cao, Y Ge, J Ran, F Sun, Q Zeng… - European heart …, 2021 - academic.oup.com
Aims We estimated the association between outdoor light at night at the residence and risk
of coronary heart disease (CHD) within a prospective cohort of older adults in Hong Kong …

Role of the circadian system in cardiovascular disease

SS Thosar, MP Butler, SA Shea - The Journal of clinical …, 2018 - Am Soc Clin Investig
All species organize behaviors to optimally match daily changes in the environment, leading
to pronounced activity/rest cycles that track the light/dark cycle. Endogenous, approximately …

Circadian-regulated cell death in cardiovascular diseases

I Rabinovich-Nikitin, B Lieberman, TA Martino… - Circulation, 2019 - Am Heart Assoc
Background: Over the past several years, a variety of human and animal studies have
shown that circadian clocks regulate biological cardiovascular rhythms in both health and …