This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

The serotonergic system plays important roles in both physiological and pathological
processes, and is a therapeutic target for many psychiatric disorders. Although several …

Recording brain neural signals and optogenetic neuromodulations open frontiers in
decoding brain neural information and neurodegenerative disease therapeutics …

Striosomes form neurochemically specialized compartments of the striatum embedded in a
large matrix made up of modules called matrisomes. Striosome-matrix architecture is …

Lasker's award-winning drug propofol is widely used in general anesthesia. The
recreational use of propofol is reported to produce a well-rested feeling and euphoric state; …

The persistence of drug taking despite its adverse consequences plays a central role in the
presentation, diagnosis, and impacts of addiction. Eventual recognition and appraisal of …

Compulsive drug use, a cardinal symptom of drug addiction, is characterized by persistent
substance use despite adverse consequences. However, little is known about the neural …

In the face of a global epidemic of drug addiction, neglecting to develop new effective
therapies will perpetuate the staggering human and economic costs of substance use. This …

Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …