ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation
Effective immunity requires the innate immune system to distinguish foreign nucleic acids
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …
from cellular ones. Cellular double-stranded RNAs (dsRNAs) are edited by the RNA-editing …
The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways
T Nakahama, Y Kawahara - International Immunology, 2023 - academic.oup.com
Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-editing enzyme that catalyzes
adenosine-to-inosine conversions in double-stranded RNAs (dsRNAs). In mammals …
adenosine-to-inosine conversions in double-stranded RNAs (dsRNAs). In mammals …
Generation of a new Adar1p150−/− mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis
The RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is an essential
regulator of the innate immune response to both cellular and viral double-stranded RNA …
regulator of the innate immune response to both cellular and viral double-stranded RNA …