Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone
cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on …

Osteocalcin is among the most abundant proteins in bone and is produced exclusively by
osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies …

The strength of bone depends on bone quantity and quality. Osteocalcin (Ocn) is the most
abundant noncollagenous protein in bone and is produced by osteoblasts. It has been …

Interactions between bone and the reproductive system have until now been thought to be
limited to the regulation of bone remodeling by the gonads. We now show that, in males …

Most physiological functions originate with the communication between organs. Mouse
genetics has revived this holistic view of physiology through the identification of inter-organ …

Bone has traditionally been regarded as a static structural organ that supports movement of
the body and protects the internal organs. However, evidence has been accumulated in the …

In addition to its structural role, the skeleton serves as an endocrine organ that controls
mineral metabolism and energy homeostasis. Three major cell types in bone-osteoblasts …

Osteoporosis is an important age-related bone disease characterized by increased bone
turnover with insufficient bone formation relative to bone resorption. According to the current …

Maintaining a constant level of blood Ca 2+ is essential because of calcium's myriad
intracellular and extracellular roles. The CaSR plays key roles in maintaining Ca 2+ o …