Adolescence encompasses a sensitive developmental period of enhanced clinical
vulnerability to nicotine, tobacco, and e‐cigarettes. While there are sociocultural influences …

Adolescence is a time of major plasticity of brain systems that regulate motivated behavior
and cognition, and is also the age of peak onset of nicotine use. Although there has been a …

Developmental periods such as gestation and adolescence have enhanced plasticity
leaving the brain vulnerable to harmful effects from nicotine use. Proper brain maturation …

A Molecular Basis for Nicotine as a Gateway Drug | New England Journal of Medicine Skip to
main content Access provided byUT MD ANDERSON CANCER CENTER The New England …

Nicotinic acetylcholine receptors (nAChRs) regulate critical aspects of brain maturation
during the prenatal, early postnatal, and adolescent periods. During these developmental …

Abstract The Gateway Hypothesis describes how tobacco or alcohol use precedes
marijuana and other illicit drug use. We review the epidemiological data, explore the …

Given the rise in teenage use of electronic nicotine delivery systems (“vaping”) in
congruence with the increasing numbers of drug-related emergencies, it is critical to expand …

Studies using animal models of adolescent exposure to alcohol, nicotine, cannabinoids, and
the stimulants cocaine, 3, 4-methylenedioxymethampethamine and methamphetamine have …

In human populations, cigarettes and alcohol generally serve as gateway drugs, which
people use first before progressing to marijuana, cocaine, or other illicit substances. To …

Background Tobacco and cannabis are among the most commonly used psychoactive
substances worldwide, and are often used in combination. Evidence suggests that tobacco …