During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …

Mouse models have enabled breakthroughs in our understanding of the immune system, but
it has become increasingly popular to emphasize their shortcomings when translating …

Infection by protozoan parasites of the genus Leishmania results in the development of
leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people …

Humans are infected with a variety of acute and chronic pathogens over the course of their
lives, and pathogen-driven selection has shaped the immune system of humans. The same …

The development of senescence in tissues of different organs and in the immune system are
usually investigated independently of each other although during ageing, senescence in …

Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in
several conditions. However, we have little understanding of the mechanisms by which …

T cell responses are essential for appropriate protection against pathogens. T cell immunity
is achieved through the ability to discriminate between foreign and self-molecules, and this …

Conventional memory CD8+ T cells and mucosal-associated invariant T cells (MAIT cells)
are found in blood, liver, and mucosal tissues and have similar effector potential following …