Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Post-translational modification with ubiquitin is required for cell division, differentiation, and
survival in all eukaryotes. As part of an intricate signaling code, ubiquitin is attached to its …

Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis
(NASH)—an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear …

The dependency of cancer cells on iron increases their susceptibility to ferroptosis, thus
providing new opportunities for patients with treatment-resistant tumors. However, we show …

The non-Bloch band theory can describe energy bands in a one-dimensional (1D) non-
Hermitian system. On the other hand, whether the non-Bloch band theory can be extended …

Aberrant overexpression or activation of EGFR drives the development of non-small cell
lung cancer (NSCLC) and acquired resistance to EGFR tyrosine kinase inhibitors (TKIs) by …

Autophagy is closely related to the occurrence and development of human malignancies;
however, the detailed mechanisms underlying autophagy in cervical cancer require further …

Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency
through compartmentalizing DNPS enzymes during stressed conditions. However, the …

The microscopic origin of chirality, possible electric-field induced static rotational lattice
deformation, and rotation-field induced electric polarization are investigated. By building up …

In all eukaryotes, autophagy is the main pathway for nutrient recycling, which encapsulates
parts of the cytoplasm and organelles in double-membrane vesicles, and then fuses with …