A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

All eukaryotic cells prepare for cell division by forming a “mitotic spindle”—a bipolar machine
made from microtubules (MTs) and many associated proteins. This device organizes the …

The mammalian MST kinase family, which is related to the Hippo kinase in Drosophila
melanogaster, includes five related proteins: MST1 (also called STK4), MST2 (also called …

The contractile ring is a complex molecular apparatus which physically divides many
eukaryotic cells. Despite knowledge of its protein composition, the molecular architecture of …

The septation initiation network (SIN) regulates aspects of cell growth and division in
Schizosaccharomyces pombe and is essential for cytokinesis. Insufficient signalling results …

The Hippo tumour suppressor pathway has emerged as a critical regulator of tissue growth
through controlling cellular processes such as cell proliferation, death, differentiation and …

Multiple protein kinases regulate cell-cycle progression, of which the cyclin-dependent
kinases (CDKs) are thought to act as upstream master regulators. We have used quantitative …

The metazoan Hippo pathway is an essential tumour suppressor signalling cascade that
ensures normal tissue growth by co-ordinating cell proliferation, cell death and cell …

mRNA half-lives are transcript-specific and vary over a range of more than 100-fold in
eukaryotic cells. mRNA stabilities can be regulated by sequence-specific RNA-binding …

One of the central pathways to problem gambling (PG) is gambling to cope with negative
moods, which is a cardinal feature of depression. Insecure attachment styles are also …