From NASH to HCC: current concepts and future challenges

QM Anstee, HL Reeves, E Kotsiliti, O Govaere… - Nature reviews …, 2019 - nature.com
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …

[PDF][PDF] Detection of circulating tumor cells and their implications as a biomarker for diagnosis, prognostication, and therapeutic monitoring in hepatocellular carcinoma

JC Ahn, PC Teng, PJ Chen, E Posadas, HR Tseng… - …, 2021 - Wiley Online Library
Hepatocellular carcinoma (HCC) is among the leading causes of worldwide cancer‐related
morbidity and mortality. Poor prognosis of HCC is attributed primarily to tumor presentation …

Circulating tumor cell detection technologies and clinical utility: Challenges and opportunities

Z Habli, W AlChamaa, R Saab, H Kadara, ML Khraiche - Cancers, 2020 - mdpi.com
The potential clinical utility of circulating tumor cells (CTCs) in the diagnosis and
management of cancer has drawn a lot of attention in the past 10 years. CTCs disseminate …

Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA

Q Ye, S Ling, S Zheng, X Xu - Molecular cancer, 2019 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of
death worldwide. Due to latent liver disease, late diagnosis, and nonresponse to systemic …

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

JW Valle, H Wasan, A Lopes, AC Backen… - The Lancet …, 2015 - thelancet.com
Background Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for
patients with advanced biliary tract cancer; expression of VEGF and its receptors is …

Circulating tumour cells in the-omics era: how far are we from achieving the 'singularity'?

TH Visal, P den Hollander, M Cristofanilli… - British journal of …, 2022 - nature.com
Over the past decade, cancer diagnosis has expanded to include liquid biopsies in addition
to tissue biopsies. Liquid biopsies can result in earlier and more accurate diagnosis and …

Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture

F Grillet, E Bayet, O Villeronce, L Zappia, EL Lagerqvist… - Gut, 2017 - gut.bmj.com
Objective Although counting of circulating tumour cells (CTC) has attracted a broad interest
as potential markers of tumour progression and treatment response, the lack of functional …

Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA

J Li, X Han, X Yu, Z Xu, G Yang, B Liu, P Xiu - Journal of Experimental & …, 2018 - Springer
Hepatocellular carcinoma (HCC) is a highly malignant disease with a poor prognosis and
high mortality due to a low early diagnosis rate, resistance to systemic treatments and …

Liquid biopsy for liver diseases

J Mann, HL Reeves, AE Feldstein - Gut, 2018 - gut.bmj.com
With the growing number of novel therapeutic approaches for liver diseases, significant
research efforts have been devoted to the development of liquid biopsy tools for precision …

Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma

J Yu, W Xiao, S Dong, H Liang, Z Zhang, B Zhang… - BMC cancer, 2018 - Springer
Background This study explored the effect of liver resection on perioperative circulating
tumor cells (CTCs) and found that the prognostic significance of surgery was associated with …