The catalytic cycle of the enzyme adenylate kinase involves large conformational motions
between open and closed states. A previous single-molecule experiment showed that …

A large conformational heterogeneity of human NAD (P) H: quinone oxidoreductase 1
(NQO1), a flavoprotein associated with various human diseases, has been observed to …

The utilization of fluorine probes in protein research has advanced our understanding of the
nature of macromolecules. The diverse activities of proteins are governed by intricate weak …

The mechanochemical coupling and biological function of myosin motors are regulated by
Ca 2+ concentrations. As one of the regulation pathways, Ca 2+ binding induces a …

Collision-induced unfolding (CIU) has provided new levels of understanding of the stabilities
and structure (s) for gas phase protein and protein complex ions formed by electrospray …

We aim to elucidate the molecular mechanism of the reciprocal relation of calmodulin's
(CaM) target binding and its affinity for calcium ions (Ca2+), which is central to decoding …

A large conformational heterogeneity of human NAD (P) H: quinone oxidoreductase 1
(NQO1), a flavoprotein associated with various human diseases, has been observed to …

Engineering naturally occurring proteins enables us to customize affinity domains according
to our specific needs, tailoring them to become an important tool in a wide array of …

Proteins are dynamic entities that constantly undergo conformational changes, influenced by
factors such as temperature and ligand binding. Therefore, understanding protein dynamics …