Two type I topoisomerases maintain DNA topology in human mitochondria
Genetic processes require the activity of multiple topoisomerases, essential enzymes that
remove topological tension and intermolecular linkages in DNA. We have investigated the …
remove topological tension and intermolecular linkages in DNA. We have investigated the …
The TDRD3-USP9X complex and MIB1 regulate TOP3B homeostasis and prevent deleterious TOP3B cleavage complexes
TOP3B is stabilized by TDRD3. Hypothesizing that TDRD3 recruits a deubiquitinase, we find
that TOP3B interacts with USP9X via TDRD3. Inactivation of USP9X destabilizes TOP3B …
that TOP3B interacts with USP9X via TDRD3. Inactivation of USP9X destabilizes TOP3B …
Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life
K Tan, YC Tse-Dinh - Cells, 2024 - mdpi.com
Topoisomerases regulate the topological state of cellular genomes to prevent impediments
to vital cellular processes, including replication and transcription from suboptimal …
to vital cellular processes, including replication and transcription from suboptimal …
Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity
Abstract The Topoisomerase 3B (Top3b)-Tudor domain containing 3 (Tdrd3) protein
complex is the only dual-activity topoisomerase complex that can alter both DNA and RNA …
complex is the only dual-activity topoisomerase complex that can alter both DNA and RNA …
A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation
S Su, Y Xue, SK Lee, Y Zhang, J Fan, S De… - Nucleic Acids …, 2023 - academic.oup.com
Topoisomerases are required to release topological stress generated by RNA polymerase II
(RNAPII) during transcription. Here, we show that in response to starvation, the complex of …
(RNAPII) during transcription. Here, we show that in response to starvation, the complex of …
RNA-binding protein Nocte regulates Drosophila development by promoting translation reinitiation on mRNAs with long upstream open reading frames
T Zhang, Y Xue, S Su, V Altouma, K Ho… - Nucleic Acids …, 2024 - academic.oup.com
RNA-binding proteins (RBPs) with intrinsically disordered regions (IDRs) are linked to
multiple human disorders, but their mechanisms of action remain unclear. Here, we report …
multiple human disorders, but their mechanisms of action remain unclear. Here, we report …
RNA Targets and Function of Topoisomerase 3β in Reducing Cellular Stress
S Teimuri, B Suter - bioRxiv, 2023 - biorxiv.org
Abstract Topoisomerase 3β (Top3β) relaxes DNA and RNA, and its dysregulation is
implicated in neurodevelopmental and cognitive disorders. We used a novel protocol …
implicated in neurodevelopmental and cognitive disorders. We used a novel protocol …
Topoisomerase 3b is dispensable for replication of a positive-sense RNA virus--murine coronavirus
A recent study demonstrated that a DNA-RNA dual-activity topoisomerase complex, TOP3B-
TDRD3, is required for normal replication of positive-sense RNA viruses, including several …
TDRD3, is required for normal replication of positive-sense RNA viruses, including several …