Astrocytes are the main cell type responsible for the regulation of brain homeostasis,
including the maintenance of ion gradients and neurotransmitter clearance. These …

During the last two decades numerous research teams demonstrated that skeletal muscles
function as an exercise-dependent endocrine organ secreting dozens of myokines. Variety …

Stimulus-dependent elevation of intracellular Ca2+ ([Ca2+] i) affects the expression of
numerous genes–a phenomenon known as excitation-transcription coupling. Recently, we …

Recent studies demonstrated that in addition to Na+, K+-ATPase inhibition cardiotonic
steroids (CTSs) affect diverse intracellular signaling pathways. This study examines the …

Our review focuses on the recent data showing that gene transcription and translation are
under the control of signaling pathways triggered by modulation of the intracellular …

Na+, K+-ATPase is the only known receptor of cardiotonic steroids (CTS) whose interaction
with catalytic α-subunits leads to inhibition of this enzyme. As predicted, CTS affect …

Ouabain is of cardiotonic steroids (CTS) family that is plant-derived compounds and is
known for many years as therapeutic and cytotoxic agents. They are specific inhibitors of Na …

Cell death is accompanied by the dissipation of electrochemical gradients of monovalent
ions across the plasma membrane that, in turn, affects cell volume via modulation of …

Previously, we reported that Ca 2+ depletion increased permeability of the plasma
membrane for Na+. This study examined the relative impact of [Na+] i/[K+] i-mediated …

Maintenance of non-equilibrium Na+ and K+ distribution between cytoplasm and
extracellular medium suggests existence of sensors responding with conformational …