The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …

The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …

The extracellular matrix (ECM) is a complex and dynamic meshwork of cross-linked proteins
that supports cell polarization and functions and tissue organization and homeostasis. Over …

Proteolysis of structural molecules of the extracellular matrix (ECM) is an irreversible post-
translational modification in all arthropathies. Common joint disorders, including …

Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate
use of standardized nomenclature for OA that could serve as building blocks for describing …

Perlecan, a large basement membrane heparan sulfate proteoglycan, is expressed in a
wide array of tissues where it regulates diverse cellular processes including bone formation …

Osteoarthritis (OA) is a disease of the whole joint organ, characterized by the loss of
cartilage, and structural changes in bone including the formation of osteophytes, causing …

Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite
the global burden of OA, diagnostic tests and treatments for the molecular or early …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …