Advances in the development of biomarkers for epilepsy
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …
remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs …
[HTML][HTML] Retinoic acid-related orphan receptors (RORs): regulatory functions in immunity, development, circadian rhythm, and metabolism
DN Cook, HS Kang, AM Jetten - Nuclear receptor research, 2015 - ncbi.nlm.nih.gov
In this overview, we provide an update on recent progress made in understanding the
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …
mechanisms of action, physiological functions, and roles in disease of retinoic acid related …
Hydrological response of an afforested catchment in a Mediterranean humid mountain area: a comparative study with a natural forest
E Nadal‐Romero, E Cammeraat… - Hydrological …, 2016 - Wiley Online Library
The effects of afforestation on water resources are still controversial. The aim of this paper is
to (i) analyse the hydrological response of an afforested area in the Central Pyrenees and …
to (i) analyse the hydrological response of an afforested area in the Central Pyrenees and …
Determination of the optimal concentration of valproic acid in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis
H Nakashima, K Oniki, M Nishimura, N Ogusu… - Plos one, 2015 - journals.plos.org
Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs for the treatment
of epileptic seizures. Although it is well known that the doses of VPA and its plasma …
of epileptic seizures. Although it is well known that the doses of VPA and its plasma …
RORA-neurodevelopmental disorder: a unique triad of developmental disability, cerebellar anomalies, and myoclonic seizures
M Talarico, J de Bellescize, M De Wachter… - Genetics in …, 2024 - Elsevier
Purpose RORA encodes the RAR-related orphan receptor-α (RORα), playing a pivotal role
in cerebellar maturation and function. Here, we report the largest series of individuals with …
in cerebellar maturation and function. Here, we report the largest series of individuals with …
Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and …
J Peng, Q Li, L Liu, P Gao, L Xing, L Chen, H Liu… - Metabolic Brain …, 2024 - Springer
This study was to investigate the mechanism of Changma Xifeng tablet, a traditional
Chinese medicine in the treatment of Tourette syndrome. Network pharmacology was …
Chinese medicine in the treatment of Tourette syndrome. Network pharmacology was …
Association Between RORA Polymorphisms and Obesity
S Azizi, P Esmaeili Motlagh, S Eslami… - Biochemical …, 2024 - Springer
RORα is a transcription factor encoded by RORA gene. This protein is involved in several
metabolic conditions, including obesity. We assessed association between two …
metabolic conditions, including obesity. We assessed association between two …
DNA methylation alterations induced by transient exposure of MCF-7 cells to maghemite nanoparticles
RS Bonadio, AC Arcanjo, ECD Lima… - …, 2017 - Taylor & Francis
Aim: To evaluate the DNA methylation profile of MCF-7 cells during and after the treatment
with maghemite nanoparticles (MNP-CIT). Materials & methods: Noncytotoxic MNP-CIT …
with maghemite nanoparticles (MNP-CIT). Materials & methods: Noncytotoxic MNP-CIT …
The association of RAR‐related orphan receptor A (RORA) gene polymorphisms with the risk of asthma
X Cai, M Lin, S Cao, Y Liu, N Lin - Annals of human genetics, 2018 - Wiley Online Library
Asthma is a common, heterogeneous chronic respiratory disease characterized by chronic
inflammation of the airway, airway hyperreactivity, and airway remodeling. The RAR‐related …
inflammation of the airway, airway hyperreactivity, and airway remodeling. The RAR‐related …
SCN1A IVS5N+ 5 G> A polymorphism and risk of febrile seizure and epilepsy: A systematic review and meta-analysis
J Hao, H Liu, J Ma, G Liu, G Dong, P Liu… - Frontiers in …, 2020 - frontiersin.org
Background: Previous studies had investigated the association between polymorphism of
IVS5N+ 5 G> A in SCN1A and the risk of febrile seizure and epilepsy. However, the results …
IVS5N+ 5 G> A in SCN1A and the risk of febrile seizure and epilepsy. However, the results …