A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

In this article the design of hybrid molecules that covalently connect two distinct drug entities
in one molecule, at least one part being a biologically active natural product will be …

In 1985 the first lamellarins were isolated from a small oceanic sea snail. Today, more than
50 lamellarins have been inventoried and numerous derivatives synthesized and tested as …

Microtubules form crucial dynamic structural cellular components of the cell and are
composed of the alpha beta tubulin heterodimers. Microtubules are involved in a wide …

Background: Higenamine is a stimulant with cardiovascular properties recently prohibited in
sport by the World Anti-Doping Agency (WADA). Higenamine is also a natural constituent of …

Tubulin protein is one of several members of a small family of globular proteins. It offers a
potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a …

A library of substituted chromeno [3, 4-b] indoles was developed as Lamellarin isosters.
Synthesis was achieved from indoles after a four-step pathway sequence involving C-3 …

Cu( ii ) catalyzed oxidation-[3+2] cycloaddition-aromatization cascade: Efficient synthesis of
pyrrolo [2, 1- a ] isoquinolines - Chemical Communications (RSC Publishing) DOI:10.1039/C0CC03186K …

This review covers recent literature on the lamellarins, a family of marine natural products,
and related analogs, encompassing synthetic strategies for total synthesis, structure–activity …

The growing interest in anticancer hybrids in the last few years has resulted in a great
number of reports on hybrid design, synthesis and bioevaluation. Many novel multi-target …