Group A Streptococcus (GAS; Streptococcus pyogenes) is a nearly ubiquitous human
pathogen responsible for a significant global disease burden. No vaccine exists, so …

Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell
membrane during the cell death program pyroptosis. GSDMs are activated by proteolytic …

Lungs are important respiratory organs primarily involved in gas exchange. Lungs interact
directly with the environment and their primary function is affected by several inflammatory …

SUMMARY Group A Streptococcus (GAS), also known as Streptococcus pyogenes, is a
clinically well-adapted human pathogen that harbors rich virulence determinants …

Probiotic supplements are suggested to promote human health by preventing pathogen
colonization. However, the mechanistic bases for their efficacy in vivo are largely …

Streptococcus pyogenes is a globally prominent human-specific pathogen responsible for
an enormous burden of human illnesses, including> 600 million pharyngeal and> 100 …

Abstract Background Pulmonary damage by Pseudomonas aeruginosa during cystic fibrosis
lung infection and ventilator-associated pneumonia is mediated both by pathogen virulence …

Group A Streptococcus (GAS, Streptococcus pyogenes) is a professional human pathogen
that commonly infects the skin. Keratinocytes are one of the first cells to contact GAS, and by …

Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response
persists throughout the course of the disease and the inflammatory and immune responses …

Currently, urbanization is associated with an increase in air pollutants that contribute to
invasive pathogen infections by altering the host's innate immunity and antimicrobial …