Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural
diseases, metabolic disorders and early death in the newborns of humans, mice and rats …

WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for
Alzheimer's disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal …

Cannabidiol (CBD) is a non-psychoactive phytocannabinoid that has been discussed for its
safety and efficacy in cancer treatments. For this reason, we have inquired into its use on …

For many decades genomic instability is considered one of the hallmarks of cancer. Role of
the tumor suppressor WWOX (WW domain-containing oxidoreductase) in DNA damage …

Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together
induces apoptosis and tumor suppression. To understand the molecular action, here we …

Malignant cancer cells frequently secrete significant amounts of transforming growth factor
beta (TGF-β), hyaluronan (HA) and hyaluronidases to facilitate metastasizing to target …

Aggregated vesicle-trafficking protein isoform TRAPPC6AΔ (TPC6AΔ) has a critical role in
causing caspase activation, tau aggregation and Aβ generation in the brains of …

Hyaluronidase HYAL-2 is a membrane-anchored protein and also localizes, in part, in the
lysosome. Recent study from animal models revealed that both HYAL-1 and HYAL-2 are …

Frostbite injury refers to cold tissue injury which typically affects the peripheral areas of the
body, and is associated with limb loss and high rates of morbidity. Historically, treatment …

Metastatic cancer cells are frequently deficient in WWOX protein or express dysfunctional
WWOX (designated WWOXd). Here, we determined that functional WWOX-expressing …