The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Abstract The Research Domain Criteria (RDoC), developed by the National Institute of
Mental Health as a neuroscience-informed alternative to traditional psychiatric nosology, is …

Recently, functional network connectivity (FNC, defined as the temporal correlation among
spatially distant brain networks) has been used to examine the functional organization of …

Major depressive disorder (MDD) is characterized by altered intrinsic functional connectivity
within (intra-iFC) intrinsic connectivity networks (ICNs), such as the Default Mode-(DMN) …

Importance Previous evidence has implicated corticostriatal abnormalities in the
pathophysiology of psychosis. Although the striatum is the primary target of all efficacious …

In schizophrenia, consistent structural and functional changes have been demonstrated for
the insula including aberrant salience processing, which is critical for psychosis. Interactions …

Over the last few decades, advances in human and animal‐based techniques have greatly
enhanced our understanding of the neural mechanisms underlying psychiatric disorders …

Schizophrenia has been conceptualized as a disorder of altered brain connectivity (ie
dysconnectivity). Until relatively recently, it was not feasible to test dysconnectivity …

Translational neuroimaging requires approaches and techniques that can bridge between
multiple different species and disease states. One candidate method that offers insights into …

Resting state networks (RSNs) are thought to reflect the intrinsic functional connectivity of
brain regions. Alterations to RSNs have been proposed to underpin various kinds of …