Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

The mammalian gastrointestinal tract is colonized with a majority of gut microbes, affecting
host metabolism and homeostasis. Gut microbiota plays a vital role in nutrient exchange …

Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and
luminal exposures but converge on a shared transcriptional program, including expression …

Research on precancers, as defined as at-risk tissues and early lesions, is of high
significance given the effectiveness of early intervention. We discuss the need for risk …

Complex multicellular organisms have evolved specific mechanisms to replenish cells in
homeostasis and during repair. Here, we discuss how emerging technologies (eg, single …

Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms
of treatment, contributing to poor survival outcomes. The incidence of pancreatic cancer is …

Background & Aims Transformation of stem/progenitor cells has been associated with
tumorigenesis in multiple tissues, but stem cells in the stomach have been hard to localize …

Insufficient functional β-cell mass causes diabetes; however, an effective cell replacement
therapy for curing diabetes is currently not available. Reprogramming of acinar cells toward …

While adult pancreatic stem cells are thought not to exist, it is now appreciated that the
acinar compartment harbors progenitors, including tissue-repairing facultative progenitors …

Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are bona fide precursor
lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs …