Site-specific DNA recombination systems have considerable utility in manipulating DNA and
can facilitate many cloning and gene transfer techniques. The ability of a number of …

We have identified a conserved family of genes related to Drosophila eag, which encodes a
distinct type of voltage-activated K+ channel. Three related genes were recovered in …

We report the identification, characterization, and cloning of a novel Drosophila circadian
rhythm gene, dClock. The mutant, initially called Jrk, manifests dominant effects …

The cloning of double-time (dbt) is reported. DOUBLETIME protein (DBT) is most closely
related to human casein kinase Iε. dbt S and dbt L mutations, which alter period length of …

Using a protein interaction cloning technique, we identified cDNAs that encode a novel Bcl-2-
binding protein, termed BAG-l. The BAG-1 protein shares no significant homology with Bci-2 …

TEMPERATURE-sensitive paralysis is the most striking defect of adult Drosophila carrying
the shibire mutation1. This is believed to be due to a reversible block of endocytosis, which …

The WW domain has previously been described as a motif of 38 semiconserved residues
found in seemingly unrelated proteins, such as dystrophin, Yes-associated protein (YAP) …

The embryonic lethal abnormal visual system (elav) gene of Drosophila melanogaster is
required for the development and maintenance of the nervous system. Transcripts from this …

Three dominant mutations of mec-4, a gene needed for mechanosensation, cause the touch-
receptor neurons of Caenorhabditis elegans to degenerate. With deg-1, another C. elegans …

We report cDNA cloning and characterization of the human and mouse orthologs of the
chicken YAP (Yes-associated protein) gene which encodes a novel protein that binds to the …