The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Natural berberine-derived azolyl ethanols as new structural antibacterial agents were
designed and synthesized for fighting with dreadful bacterial resistance. Partial target …

Over the past decades, a tremendous rise in invasive fungal infection diseases attributed to
the yeast Candida albicans in immunocompromised individuals poses a seriously …

The extensive use of antifungal drugs has resulted in severe drug resistance, making clinical
treatment of fungal infections more difficult. Biofilm inhibitors can overcome drug resistance …

Invasive fungal infections (particularly candidiasis) are emerging as severe infectious
diseases worldwide. Because of serious antifungal drug resistance, therapeutic efficacy of …

Azole antifungals inhibit the biosynthesis of ergosterol, the fungal equivalent of cholesterol
in mammalian cells. Here we report an investigation of the activity of coumarin-substituted …

Invasive fungal infections are emerging as serious infectious diseases worldwide. Because
of the development of antifungal drug resistance, the limited efficacy of the existing drugs …

In our previous study, coumarin-containing CYP51 inhibitor A32 demonstrated potent
antiresistance activity. However, compound A32 demonstrated unsatisfied metabolic …

In order to develop new triazole derivatives, we optimized the lead compound a6 by
structural modifications to obtain a series of (2R, 3R)-3-((1-substituted-1H-1, 2, 3-triazol-4-yl) …

Triazoles have demonstrated significant efficacy in the treatment of fungal infections.
However, increasing drug resistance is a growing concern that negatively impacts their …