Conditions including heating mode, time, temperature, pH, moisture and protein
concentration, shear, and the presence of alcohols, chaotropic/reducing agents, enzymes …

Most of the neurological disorders in the brain are caused by the abnormal buildup of
misfolded or aggregated proteins. Osmolytes are low molecular weight organic molecules …

We have studied here using a number of biophysical tools the effects of osmolytes, betaine,
citrulline, proline and sorbitol which differ significantly in terms of their physical …

Amyloid fibrillation of proteins and polypeptides and their deposition in cells and tissues is
associated with a number of pathological states collectively known as amyloid disorders …

Heparin is one of the members of the glycosaminoglycan (GAG) family, which has been
associated with protein aggregation diseases including Alzheimer's disease, Parkinson's …

Bovine serum albumin (BSA) is an important transport protein of the blood and its
aggregation/fibrillation would adversely affect its transport ability leading to metabolic …

Insulin fibril formation is considered as the hallmark of several debilitating pathological
conditions. To develop effective therapeutics that are able to control the amyloidogenesis …

We studied the effects of temperature and hydrostatic pressure on the dynamical properties
and folding stability of highly concentrated lysozyme solutions in the absence and presence …

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are proteins and protein segments that usually do not acquire well-defined folded structures …

Trimethylamine-N-oxide (TMAO) is a low molecular weight metabolite whose production is
dependent on metabolism of its precursors choline, carnitine, creatinine, betaine or lecithin …