Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial …

The aging and elderly population are particularly susceptible to cardiovascular disease. Age
is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are …

Cardiovascular diseases create an important burden on the public health systems,
especially in the elderly, mostly because this group of patients frequently suffer from multiple …

Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-
OP) risk model to estimate 5-and 10-year risk of cardiovascular disease (CVD) in individuals …

It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

Cardiovascular diseases (CVDs) are the leading cause of premature death and disability in
humans and their incidence is on the rise globally. Given their substantial contribution …

Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …