Epigenetic research has accelerated rapidly in the twenty-first century, generating justified
excitement and hope, but also a degree of hype. Here we review how the field has evolved …

Heterochromatin is a key architectural feature of eukaryotic chromosomes, which endows
particular genomic domains with specific functional properties. The capacity of …

Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-
coding RNA (sncRNA) discovery, the currently widely used complementary DNA library …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell
memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and …

Differential gene expression gives rise to the many cell types of complex organisms.
Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit …

Successful cloning of monkeys, the first non-human primate species, by somatic cell nuclear
transfer (SCNT) attracted worldwide attention earlier this year. Remarkably, it has taken …

Antagonism of protein–protein interactions (PPIs) with small molecules is becoming more
feasible as a therapeutic approach. Successful PPI inhibitors tend to target proteins …

Pioneer transcription factors have the unique and important role of unmasking chromatin
domains during development to allow the implementation of new cellular programs …

During development and throughout life, a variety of specialized cells must be generated to
ensure the proper function of each tissue and organ. Chromatin plays a key role in …