When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

Nearly all animal cells contain proteins evolved to trigger the destruction of the cell in which
they reside. The activation of these proteins occurs via sequential programs, and much effort …

Commensal microbes colonize the gut epithelia of virtually all animals and provide several
benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is …

RIPK1, RIPK3, ZBP1 and TRIF, the four mammalian proteins harboring RIP homotypic
interaction motif (RHIM) domains, are key components of inflammatory signaling and …

Functional amyloids are a rapidly expanding class of fibrillar protein structures, with a core
cross-β scaffold, where novel and advantageous biological function is generated by the …

Ultra-stable fibrous structure is a hallmark of amyloids. In contrast to canonical disease-
related amyloids, emerging research indicates that a significant number of cellular amyloids …

Microbe-derived acetate activates the Drosophila immunodeficiency (IMD) pathway in a
subset of enteroendocrine cells (EECs) of the anterior midgut. In these cells, the IMD …

Abstract Receptor Interacting Protein Kinases (RIPKs) are a family of Ser/Thr/Tyr kinases
whose functions, regulation and pathophysiologic roles have remained an enigma for a long …

The balance between immunity and reproduction is essential for many key physiological
functions. We report that to maintain an optimal fertility, 20-hydroxyecdysone (20E) and the …

The murine cytomegalovirus protein M45 protects infected mouse cells from necroptotic
death and, when heterologously expressed, can protect human cells from necroptosis …