In the mid-1980s, Mosmann, Coffman, and their colleagues discovered that murine CD4+
helper T-cell clones could be distinguished by the cytokines they synthesized. The isolation …

Cytokines orchestrate the complex netuwrk of cellular interactions that regulate effector cell
functions of natural and immune resistance. Although T cells, natural killer (NK) cells and …

P HAGOCYTIC CELLS and natural killer (NK) cells are among the effector cell types of
innate resistance that represent a first line of defense against infections or foreign …

Publisher Summary Although interleukin-12 (IL-12) has been discovered only relatively
recently, a remarkable level of knowledge has been obtained for this cytokine, and many …

The fungus Candida albicans behaves as a commensal as well as a true pathogen of areas
highly enriched in dendritic cells, such as skin and mucosal surfaces. The ability of the …

To define the role of interleukin (IL) 6 in Candida albicans infection, IL-6 deficient mice were
assessed for susceptibility to systemic or gastrointestinal infection, as well as for parameters …

Candida albicans is a dimorphic fungus that causes severe opportunistic infections in
humans. Recent advances in molecular biology techniques applied to this organism …

Candida albicans, an increasingly common opportunistic pathogenic fungus, frequently
causes disease in immunodeficient but not immunocompetent hosts. Clarifying the role of …

Interleukin-12 (IL-12) is a potent immunoregulatory cytokine that is crucially involved in a
wide range of infectious diseases. In several experimental models of bacterial, parasitic …

Recent studies have documented that the immunoregulatory functions of IL-12 may play a
role in promoting endogenous protective responses during infections and/or contribute to …