Macromolecular crowding, phase separation, and homeostasis in the orchestration of bacterial cellular functions
Macromolecular crowding affects the activity of proteins and functional macromolecular
complexes in all cells, including bacteria. Crowding, together with physicochemical …
complexes in all cells, including bacteria. Crowding, together with physicochemical …
Adenosine triphosphate energy‐independently controls protein homeostasis with unique structure and diverse mechanisms
J Song - Protein Science, 2021 - Wiley Online Library
Proteins function in the crowded cellular environments with high salt concentrations, thus
facing tremendous challenges of misfolding/aggregation which represents a pathological …
facing tremendous challenges of misfolding/aggregation which represents a pathological …
Elucidating ATP's role as solubilizer of biomolecular aggregate
Proteins occurring in significantly high concentrations in cellular environments (over 100
mg/ml) and functioning in crowded cytoplasm, often face the prodigious challenges of …
mg/ml) and functioning in crowded cytoplasm, often face the prodigious challenges of …
ATP induces folding of ALS-causing C71G-hPFN1 and nascent hSOD1
J Kang, L Lim, J Song - Communications Chemistry, 2023 - nature.com
Abstract ALS-causing C71G-hPFN1 coexists in both folded and unfolded states, while
nascent hSOD1 is unfolded. So far, the mechanisms underlying their ALS-triggering …
nascent hSOD1 is unfolded. So far, the mechanisms underlying their ALS-triggering …
[HTML][HTML] Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies
M Kulbay, KY Wu, GK Nirwal, P Bélanger, SD Tran - Biomolecules, 2024 - mdpi.com
This comprehensive review investigates the pivotal role of reactive oxygen species (ROS) in
cataract formation and evaluates the potential of antioxidant therapies in mitigating this …
cataract formation and evaluates the potential of antioxidant therapies in mitigating this …
Mechanistic Insights on ATP's Role as a Hydrotrope
Hydrotropes are the small amphiphilic molecules which help in solubilizing hydrophobic
entities in an aqueous medium. Recent experimental investigation has provided convincing …
entities in an aqueous medium. Recent experimental investigation has provided convincing …
ATP biphasically modulates LLPS of TDP-43 PLD by specifically binding arginine residues
Mysteriously neurons maintain ATP concentrations of~ 3 mM but whether ATP modulates
TDP-43 LLPS remains completely unexplored. Here we characterized the effect of ATP on …
TDP-43 LLPS remains completely unexplored. Here we characterized the effect of ATP on …
A physicochemical perspective on cellular ageing
SN Mouton, AJ Boersma, LM Veenhoff - Trends in Biochemical Sciences, 2023 - cell.com
Cellular ageing described at the molecular level is a multifactorial process that leads to a
spectrum of ageing trajectories. There has been recent discussion about whether a decline …
spectrum of ageing trajectories. There has been recent discussion about whether a decline …
[HTML][HTML] NMR Dynamic View of the Destabilization of WW4 Domain by Chaotropic GdmCl and NaSCN
LZ Lim, J Song - International Journal of Molecular Sciences, 2024 - mdpi.com
GdmCl and NaSCN are two strong chaotropic salts commonly used in protein folding and
stability studies, but their microscopic mechanisms remain enigmatic. Here, by CD and …
stability studies, but their microscopic mechanisms remain enigmatic. Here, by CD and …
Tethering-induced destabilization and ATP-binding for tandem RRM domains of ALS-causing TDP-43 and hnRNPA1
M Dang, Y Li, J Song - Scientific Reports, 2021 - nature.com
TDP-43 and hnRNPA1 contain tandemly-tethered RNA-recognition-motif (RRM) domains,
which not only functionally bind an array of nucleic acids, but also participate in …
which not only functionally bind an array of nucleic acids, but also participate in …