Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity, and increased neuronal responsiveness in central pain pathways after painful …

Fibromyalgia is a disorder that is part of a spectrum of syndromes that lack precise
classification. It is often considered as part of the global overview of functional somatic …

Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …

Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic
pain, and depression frequently co-occur and are mutually interacting conditions. However …

Pain is a key component of most rheumatologic diseases. In fibromyalgia, the importance of
central nervous system pain mechanisms (for example, loss of descending analgesic activity …

Chronic pain conditions are multifactorial disorders with a high frequency in the population.
Their pathophysiology is often unclear, and treatment is inefficient. During the last 20 years …

Background Fibromyalgia often coexists and overlaps with other syndromes such as chronic
fatigue, irritable bowel syndrome, and interstitial cystitis. Chronic stress has been implicated …

This article examines the biological, genetic, and environmental aspects of fibromyalgia that
may have an impact on its pathogenesis. Symptoms of fibromyalgia may be related to …

Pain is an immense clinical and societal challenge, and the key to understanding and
treating it is variability. Robust interindividual differences are consistently observed in pain …

Musculoskeletal pain conditions, such as fibromyalgia and low back pain, tend to coexist in
affected individuals and are characterized by a report of pain greater than expected based …