F-box proteins, which are the substrate-recognition subunits of SKP1–cullin 1–F-box protein
(SCF) E3 ligase complexes, have pivotal roles in multiple cellular processes through …

Histone acetylation has been recognized as an important post‐translational modification of
core nucleosomal histones that changes access to the chromatin to allow gene transcription …

In the conventional model of transcriptional activation, transcription factors bind to response
elements and recruit co-factors, including histone acetyltransferases. Contrary to this model …

F-box proteins, which are subunit recruiting modules of SCF (SKP1-Cullin 1-F-box protein)
E3 ligase complexes, play critical roles in the development and progression of human …

HBO1 complexes are major acetyltransferase responsible for histone H4 acetylation in vivo,
which belongs to the MYST family. As the core catalytic subunit, HBO1 consists of an N …

Fbxl7, a subunit of the SCF (Skp-Cul1-F-box protein) complex induces mitotic arrest in cells;
however, molecular factors that control its cellular abundance remain largely unknown …

Fbxl7, a component of the Skp1· Cul1· F-box protein type ubiquitin E3 ligase, regulates
mitotic cell cycle progression. Here we demonstrate that overexpression of Fbxl7 in lung …

Cullin-RING (Really Interesting New Gene) E3 ubiquitin ligases (CRLs), the largest family of
E3 ubiquitin ligases, are functional multi-subunit complexes including substrate receptors …

New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among
women, are being sought, with the targeting of epigenetic modulators now receiving much …

Histone post-translational modification is a key step that may result in an epigenetic mark
that regulates chromatin structure and gene transcriptional activity thereby impacting many …