Oesophageal cancer is a global health problem; in 2018 there were more than 572,000
people newly diagnosed with oesophageal cancer worldwide. There are two main …

Oesophageal cancer is the sixth most common cause of cancer-related death worldwide
and is therefore a major global health challenge. The two major subtypes of oesophageal …

The incidence of esophageal adenocarcinoma (EAC) has increased in many Western
countries and is higher in men than women. Some risk factors for EAC have been identified …

Background Oesophageal adenocarcinoma is the sixth most common cause of cancer death
worldwide and Barrett's oesophagus is the biggest risk factor. We aimed to evaluate the …

Oesophageal cancer is a clinically challenging disease that requires a multidisciplinary
approach. Extensive treatment might be associated with a considerable decline in health …

Objective Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology
primarily attributable to its symptom-based definitions. GERD genome-wide association …

Genome-wide association studies (GWAS) have led to the identification of hundreds of
susceptibility loci across cancers, but the impact of further studies remains uncertain. Here …

Lung cancer is the number one cause of cancer-related deaths. The malignancy is
characterized by dismal prognosis and poor clinical outcome mostly due to advanced-stage …

Barrett oesophagus, in which a metaplastic columnar mucosa that can predispose
individuals to cancer development lines a portion of the distal oesophagus, is the only …

Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …