Animal models refers to the animal experimental objects and related materials that can
simulate human body established in medical research. As the second-largest disease in …

Highlights•Zebrafish are a useful tool for screening new drugs for inflammation.•This teleost
shares several inflammatory mediators and receptors with mammals.•The real-time …

The poor efficiency and drastic adverse effects of current cancer therapies entail a radical
shift in treatment paradigms, which require developing cutting-edge therapeutics in …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a 5-
year survival rate of< 10%. Aberrant activation or elevated expression of the tyrosine kinase …

Mechanisms underlying the pathogenesis of tissue fibrosis remain incompletely understood.
Emerging evidence suggests that cell adhesion molecules (CAMs) are critical in fibrotic …

Pancreatic cancer, a disease with extremely poor prognosis, has been notoriously resistant
to virtually all forms of treatment. The dynamic crosstalk that occurs between tumour cells …

RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin,
vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by …

Objective Hepatic stellate cells (HSCs) are the important players in liver cirrhosis and liver
cancer. They also act as critical mediators of immunosuppression in hepatocellular …

Accumulating evidence has shown that the traits of tumor-initiating cells (TICs) are controlled
by the microenvironment niches (MENs), but the composition and remodeling mechanisms …

Hepatic stellate cells (HSC) and hydrogen sulfide (H2S) both play important roles in the
development of hepatocellar carcinoma (HCC). Whereas, in the microenvironment of HCC …