Drugs in space: pharmacokinetics and pharmacodynamics in astronauts

J Kast, Y Yu, CN Seubert, VE Wotring… - European Journal of …, 2017 - Elsevier
Abstract Space agencies are working intensely to push the current boundaries of human
spaceflight by sending astronauts deeper into space than ever before, including missions to …

Medications in space: in search of a pharmacologist's guide to the galaxy

S Eyal, H Derendorf - Pharmaceutical research, 2019 - Springer
Medications have been used during space missions for more than half a century, yet our
understanding of the effects of spaceflight on drug pharmacokinetics and …

Microgravity: New aspect for breast cancer treatment, a review

M Medha, A Roy - Acta Astronautica, 2022 - Elsevier
Breast cancer is the most commonly occurring cancer in women and impacts around 2.1
million women each year. The drug treatment depends on the type of breast cancer and …

[PDF][PDF] Ergonomic challenges for astronauts during space travel and the need for space medicine

M Braddock - J Ergonomics, 2017 - researchgate.net
Imagine it is 2117. The technology to enable space travel approaching 1/10th the speed of
light has been developed and it is both physically and commercially feasible to send a …

Pharmacological Innovations in Space: Challenges and Future Perspectives

ZŞ Aksoyalp, A Temel, M Karpuz - Pharmaceutical Research, 2024 - Springer
Purpose Since the first human experience in space, the interest in space research and
medicine to explore universe is growing day by day. The extreme space conditions mainly …

Identification of reference genes in human myelomonocytic cells for gene expression studies in altered gravity

CS Thiel, S Hauschild, S Tauber… - BioMed research …, 2015 - Wiley Online Library
Gene expression studies are indispensable for investigation and elucidation of molecular
mechanisms. For the process of normalization, reference genes (“housekeeping genes”) are …

Microgravity effects on frozen human sperm samples

M Boada, A Perez-Poch, M Ballester… - Journal of assisted …, 2020 - Springer
Purpose Microgravity has severe effects on cellular and molecular structures as well as on
metabolic interactions. The aim of this study is to investigate the effects of microgravity (μg) …

[HTML][HTML] Differential Effect of Simulated Microgravity on the Cellular Uptake of Small Molecules

O Tepper-Shimshon, N Tetro, R Hamed, N Erenburg… - Pharmaceutics, 2024 - mdpi.com
The space environment can affect the function of all physiological systems, including the
properties of cell membranes. Our goal in this study was to explore the effect of simulated …

Construction of dose prediction model and identification of sensitive genes for space radiation based on single-sample networks under spaceflight conditions

Y Zhang, X Du, L Zhao, Y Sun - International Journal of Radiation …, 2024 - Taylor & Francis
Purpose To identify sensitive genes for space radiation, we integrated the transcriptomic
samples of spaceflight mice from GeneLab and predicted the radiation doses absorbed by …

The comparison of the apoptosis effects of titanium dioxide nanoparticles into MDA-MB-231 cell line in microgravity and gravity conditions.

A Hekmat, M Rabizadeh, M Safavi… - Nanomedicine …, 2019 - search.ebscohost.com
Objective (s): Gravity could affect some system features and perform directly as an
organizing field factor. Recent investigations have examined the titanium dioxide …