Publisher Summary This chapter discusses the mechanisms and roles of apoptosis in
pathology. Necrosis differs from apoptosis in structure, mechanism, and sequelae …

Inflammation is characterized by the local accumulation of blood leukocytes, plasma
proteins, and fluid, usually at an extravascular site of injury, infection, or antigenic …

An ultrastructural analysis of human cytotoxic T lymphocyte‐target cell (CTL‐TC) interaction
has been undertaken to enable a better understanding of the killing mechanism. Attention …

To investigate the mechanisms of T-cell-mediated cytotoxicity, we estimated the involvement
of apoptosis-inducing Fas molecule on the target cells and its ligand on the effector cells …

Vascular endothelial growth factor (VEGF) potently stimulates angiogenesis, whereas TNF-
alpha has both pro-and anti-angiogenic activity. By measuring thymidine uptake, we found …

Smac-mimetics are emerging as promising anti-cancer agents and are being evaluated in
clinical trials for a variety of malignancies. Smac-mimetics can induce TNF production from a …

The heart shares with other organs a susceptibility to immune-mediated injury. However, the
unique clinical expressions of myocardial inflammation have only recently received …

Cytotoxic CD8+ T cells (CTLs) contain virus infections through the release of granules
containing both perforin and granzymes. T cell 'exhaustion'is a hallmark of chronic persistent …

Cytotoxic T cells (CTLs) are important immune effector cells in the adaptive immune
response. It has been well documented that CTLs are important in host immune responses …

Histological and ultrastructural studies of the hearts of dogs sacrificed 18 to 26 days after
intraperitoneal inoculation with 4 x 10 (5) blood forms of the 12 SF strain of Trypanosoma …